The novel structural protein of human cytomegalovirus, pUL25, is localized in the viral tegument.
نویسندگان
چکیده
Human cytomegalovirus UL25 codes for a structural phosphoprotein of 85 kDa (C. J. Baldick and T. Shenk, J. Virol. 70:6097-6105, 1996; M. C. Battista et al., J. Virol. 73:3800-3809, 1999). In this study we analyzed the intracellular and intraviral localization of pUL25 by confocal and immunoelectron microscopy and found that pUL25 is a component of the viral tegument and the dense body matrix, acquired during the late cytoplasmic phase of virus maturation.
منابع مشابه
Expression and characterization of a novel structural protein of human cytomegalovirus, pUL25.
Human cytomegalovirus (HCMV) UL25 has recently been found to encode a new structural protein that is present in both virion and defective viral particles (C. J. Baldick and T. Shenk, J. Virol. 70:6097-6105, 1996). In the present work a polyclonal antibody was raised against a prokaryotic pUL25 fusion protein in order to investigate the biosynthesis and localization of the UL25 product (pUL25) d...
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ورودعنوان ژورنال:
- Journal of virology
دوره 73 7 شماره
صفحات -
تاریخ انتشار 1999